AUTONOMIC NERVOUS SYSTEM PHARMACOLOGY-CHOLINOMIMETIC DRUGS
Drug: Nicotine
Mechanism of action and drug effects: Agonist at both NN and NM receptors. Activates autonomic postganglionic neurons (both sympathetic and parasympathetic) and skeletal muscle neuromuscular end plates. It enters CNS and activates NN receptors.
Clinical applications: Medical use in smoking cessation. Nonmedical use in smoking and in insecticides.
Pharmacokinetics, Toxicities, Interactions: Oral gum, patch for smoking cessation. Toxicity: Increased gastrointestinal (GI) activity, nausea, vomiting, diarrhea acutely, increased blood pressure, high doses cause seizures, long-term GI and cardiovascular risk factor. Interactions: Additive with CNS stimulants.
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